Distinct, developmental stage-specific activation mechanisms of trypanosome VSG genes
نویسندگان
چکیده
منابع مشابه
A trypanosome metacyclic VSG gene promoter with two functionally distinct, life cycle stage-specific activities.
In the mammalian bloodstream, African trypanosomes express the variant surface glycoprotein (VSG), continual switching of which allows evasion of the host immune response. Bloodstream VSG genes are transcribed from polycistronic bloodstream expression sites with promoters which are located 45-60 kb upstream. These promoters are not exclusively stage-regulated, being active in the insect midgut ...
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The African trypanosomes undergo extensive development as they proceed through their life cycle, producing a range of stages with distinct functions. In response to the somewhat treacherous, extracellular environments occupied by trypanosomes in their rather different hosts mammals and tsetse flies elaborate survival mechanisms are utilized. The best known of these is antigenic variation (revie...
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Tsetse flies are biological vectors of African trypanosomes, the protozoan parasites responsible for causing human and animal trypanosomiases across sub-Saharan Africa. Currently, no vaccines are available for disease prevention due to antigenic variation of the Variant Surface Glycoproteins (VSG) that coat parasites while they reside within mammalian hosts. As a result, interference with paras...
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Gliomas represent the most common type of primary brain tumor in both children and adults, showing considerable variability in histologic appearance and clinical outcome. The phenotypic differences between types and grades of gliomas have not been explained solely on the grounds of differing oncogenic stimuli, and current evidence suggests that an interaction between the cell of origin, the tum...
متن کاملLocus-specific control of DNA resection and suppression of subtelomeric VSG recombination by HAT3 in the African trypanosome
The African trypanosome, Trypanosoma brucei, is a parasitic protozoan that achieves antigenic variation through DNA-repair processes involving Variant Surface Glycoprotein (VSG) gene rearrangements at subtelomeres. Subtelomeric suppression of DNA repair operates in eukaryotes but little is known about these controls in trypanosomes. Here, we identify a trypanosome histone acetyltransferase (HAT...
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ژورنال
عنوان ژورنال: Parasitology
سال: 1990
ISSN: 0031-1820,1469-8161
DOI: 10.1017/s0031182000060558